These were the results of an independent and investigator-initiated study (IIT CARR-COV-02, NCT04521322. Conclusion: Investigations on compatibility of xylometazoline HCl and iota-carrageenan demonstrated that the substances do not influence each other, allowing both to fulfill their known specific clinical efficacy (xylometazoline HCl) and effectiveness (iota-carrageenan). Marinomed Biotech AG announces that a nasal spray with iota-carrageenan, which is identical to Marinomed’s Carragelose®, showed significant efficacy in the prevention of COVID-19 in hospital staff who manage patients with this disease. Finally, in the local tolerance and toxicity study, it was shown that the formulation was well tolerated at the application site with no occurrence of erythema or edema in the nostrils of all rabbits or any signs of toxicity in any of the organs and tissues inspected. Permeation experiments using bovine nasal mucosa showed that iota-carrageenan had no significant influence on the permeation of xylometazoline HCl. Development of a nasal spray containing xylometazoline hydrochloride and iota-carrageenan for the symptomatic relief of nasal congestion caused by rhinitis and. Results: A set of in vitro experiments revealed that the vasoconstrictive properties of xylometazoline HCl and the antiviral effectiveness of iota-carrageenan against human rhinovirus (hRV) 1a, hRV8 and human coronavirus OC43 were maintained in the formulation containing these two compounds. Recently, we developed a nasal spray formulation containing both xylometazoline HCl (0.05%) and iota-carrageenan (0.12%) that provides decongestion and antiviral protection of the nasal mucosa at the same time. Therefore, it is used as the active component in the antiviral nasal spray Coldamaris prophylactic (1.2 mg/mL iota-carrageenan in 0.5% NaCl) and other medical device nasal sprays that are approved and marketed in the EU. Iota-Carrageenan Nasal Spray for COVID-19 Marinomed Biotech AG (VSE:MARI), an Austrian science-based biotech company with globally marketed therapeutics derived from innovative proprietary technology platforms, announced today that Carragelose inactivates the new, rapidly spreading variants and SARS-CoV-2 wildtype with similar efficacy in vitro. The reduced duration of disease was 3 days (p < 0.01) and the number of relapses was three times less (p < 0. Iota-carrageenan is effective against a broad variety of respiratory viruses, which are the most common cause of infections of the upper respiratory tract. Carrageenan nasal spray showed significant antiviral efficacy in all three virus subgroups, the highest effectiveness was observed in human corona virus-infected patients. It has been used for more than 50 years for the treatment of nasal congestion caused by rhinitis/sinusitis. Larger trials are indicated to confirm the results.Christine Graf,1 Andreas Bernkop-Schnürch,2 Alena Egyed,1 Christiane Koller,1 Eva Prieschl-Grassauer,1 Martina Morokutti-Kurz1 1Marinomed Biotech AG, Vienna, Austria 2ThioMatriX, Innsbruck, Austria Introduction: Xylometazoline hydrochloride (HCl) is a nasal decongestant that causes vasoconstriction in the nasal submucosa. Efficacy and Safety of Iota-Carrageenan Nasal Spray 1.2 g/l (0. Pro-inflammatory mediators FGF-2, Fractalkine, GRO, G-CSF, IL-8, IL-1alpha, IP-10, IL-10, and IFN-alpha2 were reduced in the Iota-Carrageenan group.ĬONCLUSIONS: Iota-Carrageenan nasal spray appears to be a promising treatment for safe and effective treatment of early symptoms of common cold. RESULTS: Administration of Iota-Carrageenan nasal spray reduced the symptoms of common cold (p = 0.046) and the viral load in nasal lavages (p = 0.009) in patients with early symptoms of common cold. Iota-Carrageenan 0.12 plus 0.04 Kappa-Carrageenan in 0.5 saline) Placebo Comparator: Coldamaris sine Coldamaris sine i.e. This helps keep the nasal tissues moist to prevent and. Carrageenan binds effectively to mucus and strongly attracts water. Carrageenan is an extract derived from marine red algae. It is aclear, colourless and odourless solution. METHODS: In a randomized, double-blind, placebo-controlled exploratory trial, 35 human subjects suffering from early symptoms of common cold received Iota-Carrageenan (0.12%) in a saline solution three times daily for 4 days, compared to placebo. Iota-carrageenan nasal and throat spray (verum Coldamaris plus i.e. FLO Travel Nasal Spray is a sterile, preservative free, non-stinging saline spray containing Carrageenan 1.6mg /ml. This study investigated the efficacy and safety of an Iota-Carrageenan nasal spray in patients with common cold symptoms. Iota-carrageenan is a sulfated polysaccharide extracted from red seaweeds, which, formulated into a nasal spray, has already been proven safe and effective. I cant think of how I might have caught it, though it might have been in a non-masking office where I took my mask off for a couple of minutes while I ate. Iota-Carrageenan is broadly active against respiratory viruses in-vitro and has an excellent safety profile. So I tested positive for COVID a couple of days ago. BACKGROUND: The common cold, the most prevalent contagious viral disease in humans still lacks a safe and effective antiviral treatment.
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